Co-inhibitory molecules: Controlling the effectors or controlling the controllers?

Mechanisms controlling the shedding of transmembrane molecules.

Although the number of cell-surface transmembrane molecules known to release their extracellular domain to the cell media has grown greatly during past years, the protease(s) involved have remained elusive until recently. The analysis of ectodomain shedding of proteins as diverse as membrane-anchored growth factors, such as pro-transforming growth factor a (proTGF-a) and pro-tumour necrosis fac...

Molecules controlling lymphocyte migration to the gut.

Comparison of Conventional and Model، Based Controllers for Controlling a Batch Polymerization Reactor

Invited Speakers Controlling Molecules on Surfaces

The motion of one molecule on a surface can cause the subsequent motion of another molecule, and so on in a cascade of molecular motion. We call such an engineered motion a “molecule cascade”. A molecule cascade is similar to a row of toppling dominoes. It offers a unique chance to study the physical mechanism of hopping molecules as well as interesting applications for information transport an...

Controlling protein transport by small molecules.

Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES). This nuclear export process can be inhibited by several small molecules, both natural products and fully synthetic compounds. The structural basis for the inhibition of nuclear export by leptomycin (LMB) based on disruption of ...